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15/09 - "The Biochemistry of Nickel: Il Buono, Il Brutto, Il Cattivo" Lecture by Michael J. Maroney, University of Massachusetts,USA

The visit of Michael J. Maroney is organised in collaboration with Francesco Musiani from the Department of Pharmacy and Biotechnology.

Sep 15, 2021 from 05:30 PM to 07:00 PM

Where Sala Rossa, Via Marsala, 26 Bologna and online on Zoom

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Nickel is named for a demon, and it is certainly capable of living up to its namesake. Showing its good side, it is inexpensive and widely employed metal in the manufacture of alloys and batteries, and in catalysis. Biologically, nickel often shows its darker side. Nickel compounds are known human carcinogens and are a leading cause of contact dermatitis. Nickel has had a major impact in the evolution of life on Earth, and It is an essential metal for many microorganisms--including being a virulence factor for a number of human pathogens. Its essentiality can be traced to catalytic centers in at least eight classes of enzymes. Given that the only common oxidation state in aqueous media is +2, it was an early surprise in the study of nickel metalloenzymes to find nickel employed as a redox center in several cases. High concentrations of transition metals are toxic to cells. To control the availability of nickel and direct it to the correct enzyme targets, proteins collectively known as ‘trafficking proteins,’ are employed. These proteins control the import/export of specific metals, regulate the expression of the importers/exporters (metallosensors), and deliver the correct metal to the enzyme target (metallochaperones). Given that there are no known human nickel metalloenzymes, these microbial nickel trafficking systems are attractive antibiotic targets. This talk will serve as a general introduction to the biochemistry of nickel and broadly focus on the molecular basis for its biological functions.

Link to ZOOM: Click here to access

If you prefer to attend this lecture in presence, you should write to segreteria.isa@unibo.it within September 15th, 12 p.m. and book your place. The places will be assigned on “first come first served” basis.

As per the Decree-Law number 111, issued on the 6th of August 2021, in order to attend lectures in presence you must have a COVID-19 Green Pass and show it on the premises.