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17 Mar - "From clinical aging towards how organisation of space is important in biology: a path from clinic to fundamental immunology and general concepts" Lecture by Jean-François Moreau, Université de Bordeaux, France

The visit of Jean-François Moreau is organised in collaboration with Stefano Salvioli from the Department of Experimental, Diagnostic and Specialty Medicine.

Mar 17, 2020 from 05:30 PM to 07:00 PM

Where Sala Rossa, Palazzo Marchesini, via Marsala 26, Bologna (first floor)

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It is widely assumed that immunosenescence involving inflamaging and cellular alterations of circulating immmune cells, relies on lifelong antigenic load and persistent CMV infection. Although these factor are important, they may not be causal but consequential to a more general age-related mechanism.

We propose that a major role is played by the age-associated irreversible alteration of the extracellular matrix (ECM) constituting the 3D microenvironment where immune cells operate. I will focus my talk to provide an integrated view on this topic. We gathered solid data from several fields outside immunology that emphasize the constraints imposed by space organization on the functioning of the immune system and I will decipher the potential consequences of the well known ECM aging in explaining immunosenescence.

The progressive and irreversible age-related alteration of the extracellular matrix, could actually provide an upstream mechanism and a unifying framework to explain the molecular and cellular features of immunosenescence altogether. I will argue that mobility of immune cells in this extracellular mesh is pivotal for an efficient immunity in young subjects but even more in the elderly where cross-linking of ECM components augments the mobility constraints and I will propose to include immune aging within a wider “evo-devo” prospective through the concept of space organization and its corollary mobility.